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For Lifewave X39 Patches specifically: Most common placement: back of the neck, base of the skull, or between the shoulder blades You can rotate between several acupressure points LifeWave provides detailed placement guides Start with X39 alone for at least 30 days before adding other patches What not to do: Don't apply to broken or irritated skin Don't use during pregnancy (LifeWave has not researched use in pregnancy) Don't wear while in a very hot bath or sauna for extended periods Don't expect overnight results this is a long-game technology